Previously, work by the Australasian Creatinine Consensus Working Group has resulted in automatic reporting of an estimated GFR (eGFR) with requests for serum creatinine concentration in individuals aged ≥ 18 years and unification of units of measurement for creatinine and GFR, and has promoted standardisation of assays. 4 Therefore, increasing the recognition of kidney damage and impaired kidney function, which is often asymptomatic, is a key part of improving health outcomes in the community. Based on data from the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study, 2, 3 it is estimated that about 6 million individuals have one or more of the major risk factors for CKD and that about 1.4 million Australian adults have CKD.Įarly identification and management of CKD is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease by up to 50%. The working group recommended that all pathology laboratories in Australia should implement the relevant recommendations as a vital component of an integrated national approach to detection of CKD.Ĭ hronic kidney disease (CKD), defined as reduced kidney function (glomerular filtration rate < 60 mL/min/1.73m 2) and/or evidence of kidney damage (usually indicated by albuminuria or proteinuria) for a period of at least 3 months, 1 is a major public health problem in Australia and throughout the world. Recommended testing algorithms and sex-specific cut-points for microalbuminuria and macroalbuminuria are provided. The working group recommended that adults with one or more risk factors for CKD should be assessed using UACR and estimated GFR every 1–2 years, depending on their risk-factor profile. Where a first-void specimen is not possible or practical, a random spot urine specimen for UACR is acceptable. The working group recommended that the preferred method for assessment of albuminuria in both diabetic and non-diabetic patients is urinary albumin-to-creatinine ratio (UACR) measurement in a first-void spot urine specimen. Measurement of urinary albuminuria and proteinuria is hindered by a lack of standardisation regarding requesting, sample collection, reporting and interpretation of tests.Ī multidisciplinary working group was convened with the goal of developing and promoting recommendations that achieve consensus on these issues. Optimal detection and subsequent risk stratification of people with chronic kidney disease (CKD) requires simultaneous consideration of both kidney function (glomerular filtration rate ) and kidney damage (as indicated by albuminuria or proteinuria). Statistics, epidemiology and research design.
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